GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4888671 | 1 | rs4888671 | chr16:77783580 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.94 | 1.09E-6 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888672 | chr16:77783666 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.94 | 1.09E-6 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888673 | chr16:77783703 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.95 | 1.04E-6 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888674 | chr16:77783749 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.95 | 1.04E-6 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888675 | chr16:77783757 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.95 | 1.04E-6 | Obesity-related traits |
| THCA | cis | rs4888671 | 1 | rs4888676 | chr16:77783896 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.94 | 1.09E-6 | Obesity-related traits |
| THCA | cis | rs3925075 | 1 | rs4889543 | chr16:31340216 | HSD3B7 | chr16:30996519-31000473:+ | -0.17 | -4.17 | 3.59E-5 | IgA nephropathy |
| THCA | cis | rs3925075 | 1 | rs4889543 | chr16:31340216 | MYST1 | chr16:31128985-31142713:+ | -0.1 | -3.52 | 0.00047 | IgA nephropathy |
| THCA | cis | rs3925075 | 1 | rs4889543 | chr16:31340216 | ZNF843 | chr16:31446885-31454348:- | -0.17 | -3.53 | 0.000452 | IgA nephropathy |
| THCA | cis | rs4889609 | 1 | rs4889609 | chr16:31026427 | C16orf93 | chr16:30768753-30773542:- | -0.15 | -4.35 | 1.66E-5 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs4889609 | chr16:31026427 | HSD3B7 | chr16:30996519-31000473:+ | 0.48 | 12.46 | 4.82E-31 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs4889609 | chr16:31026427 | MYST1 | chr16:31128985-31142713:+ | 0.16 | 5.39 | 1.13E-7 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs4889609 | chr16:31026427 | PRSS53 | chr16:31094747-31106276:- | -0.15 | -4.14 | 4.1E-5 | Response to metformin (IC50) |
| THCA | cis | rs17657012 | 1 | rs4898847 | chr14:55170103 | SAMD4A | chr14:55034637-55260033:+ | -0.28 | -3.58 | 0.000385 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs910316 | 1 | rs4899544 | chr14:75546556 | EIF2B2 | chr14:75469612-75476292:+ | 0.19 | 5.13 | 4.3E-7 | Height |